As global efforts continue to reveal more about the secrets of the Corona virus, which has exhausted humanity over two years, leaving more than 4 million deaths, a Swedish research team has come up with a new strategy that can be used to combat Covid 19, based on “virus starvation”, after their success in identifying the pathways of representation. The main nutrients that can regulate its reproduction, according to the results of a study published, Friday, in the journal “Molecular and Cellular Proteins”.
While the virus spreads, by hijacking the metabolic pathways of the host cell, which gives it a greater ability to reproduce, and by using blood samples from 41 patients with the disease, and analyzing them using different techniques, including plasma metabolism, the research team from Karolinska Institutet in Sweden identified the role of the virus. The main metabolic pathways through which the virus enters the lung tissue.
The initial observation made on Covid-19 patients during the pandemic had indicated a relationship between the severity of the disease and metabolic disorder with high levels of fats in the blood. Diet and lifestyle.
Favorite paths of the virus
In addition, the researchers discovered that glycolysis and glutaminolysis are the metabolic pathways preferred by the virus when attacking the lungs, and both are essential processes in cellular energy supply and function.
“Our results show that when the virus infects lung cells, glycolysis and glutaminolysis play an important role in its spread and growth,” said Ojwal Nyugi, a researcher in the Department of Laboratory Medicine at Karolinska Institutet and a co-author of the study, in a report published on the institute’s website in conjunction with the study’s publication. And by (starving the virus) by blocking these pathways, we can limit its reproduction.” Another key finding of the study is a biomarker of disease severity, linked to the metabolic pathway of the virus.
He added, “We identified carbohydrates, and mannose, as a biomarker of disease severity.” And “mannose”, is a monosaccharide that belongs to the group of sugars known as “hexoses”, that is, sugars that contain six carbon atoms in their molecular structure.
Millions of injuries
It is noteworthy that the Corona virus has infected more than 219 million people since the World Health Organization office in China reported the emergence of the disease at the end of December 2019. The vast majority of those infected recovered, although some continued to feel symptoms after weeks or even months.
Whereas, the World Health Organization, taking into account the excess mortality rate directly or indirectly related to Covid-19, considers that the outcome of the epidemic may be two or three times greater than the officially announced outcome.